Compound F has been used as an adjunct in the treatment of seventy hand conditions with and without operation. There have been no complications which can be exclusively ascribed to the use of the drug. Compound F has the temporary effect of minimizing inflammatory reaction. It can-in no sense be considered a cure. In cases of rheumatic origin, including arthritis, tenosynovitis, trigger finger, and the tendency of the fingers to stiffen following operations on Dupuytren's contracture, compound F is of value in temporarily ameliorating symptoms or in tiding the patient over postoperative difficulties. For major reconstructive procedures on the hand, compound F seems to be of value in minimizing the immediate postoperative reaction to surgery. In this limited series compound F did not appear to be of value in simple ganglia or in primary tendon repair.