JBJS | Article

The Journal of Bone & Joint Surgery, Volume 86, Issue 1

Case Reports | January 01, 2004

Minocycline-Induced Blue-Green Discoloration of Bone: A Case Report

Patrick E. McCleskey, USAF, MC¹; Kamala H. Littleton, MD²

¹ Department of Aerospace Medicine, David Grant Medical Center, 60AMDS/SGPF, 101 Bodin Circle, Travis Air Force Base, Fairfield, CA 94535
² Mercy Medical Center, 301 St. Paul Place, POB Suite 812, Baltimore, MD 21202. E-mail address: khlittleton@mercymed.com

The Journal of Bone & Joint Surgery. 2004; 86:146-148

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The long-term use of minocycline has been associated with skin and tooth hyperpigmentation, but cases of bone discoloration have been reported only rarely1-5. Darkly colored bone that is encountered during a routine arthroplasty presents a dilemma because of the uncertainty regarding its etiology, the structural soundness of the bone, and the ability of the bone to heal. We report the case of an elderly man with a history of long-term minocycline use in whom blue-green discoloration of bone was found during routine total knee arthroplasty. The patient was informed that data concerning this case would be submitted for publication.

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minocycline ; abnormal color

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These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.

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