JBJS | Article

The Journal of Bone & Joint Surgery, Volume 87, Issue 11

Letters to the Editor | November 01, 2005

Effect of Bisphosphonates on Periprosthetic Bone Mineral Density After Total Joint Arthroplasty

Nitin R. Shetty, MRCS; A.J. Hamer, MD, FRCS(Orth); I. Stockley, MD, FRCS; R. Eastell, MD, FRCP, F Med Sci; J.M. Wilkinson, PhD, FRCS(Orth)

The Journal of Bone & Joint Surgery. 2005; 87:2589-a-2590

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To The Editor:We read with interest the paper, "Effect of Bisphosphonates on Periprosthetic Bone Mineral Density After Total Joint Arthroplasty. A Meta-Analysis" (2005;87:293-301), by Bhandari et al. We were intrigued by the findings that the effect size of bisphosphonate therapy was greater after procedures performed with cemented implants than after those performed with uncemented implants and greater after total knee arthroplasty than after total hip arthroplasty. We noted that both of the total knee arthroplasty studies involved cemented implants but that half of the total hip arthroplasty studies involved uncemented implants. Would the authors clarify whether cementation and joint site were independent predictors of drug efficacy, or whether the greater effect after procedures involving cemented implants might have been due to the common variable effect of total knee arthroplasty?

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bone mineral density ; bisphosphonates ; arthroplasty

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These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.

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