JBJS | Article

The Journal of Bone & Joint Surgery, Volume 88, Issue 11

Letters to the Editor | November 01, 2006

Craig T. Hartrick, MD; Gavin Martin, MD

The Journal of Bone & Joint Surgery. 2006; 88:2536-2536

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C.T. Hartrick and G. Martin reply:We appreciate both Dr. Boezaart's interest and his concern. The facts do indeed speak for themselves. The adverse event figures as quoted above pertained to all groups, which included the intravenous patient-controlled analgesia with morphine arm. This highlights an important point that we hope that we made clear in our discussion but welcome the opportunity to emphasize. Morphine produces similar adverse effects regardless of the route of administration. The prevalence of side effects in all groups should be taken in the context of the study protocol, in which no prophylaxis with drugs such as ondansetron was allowed. Furthermore, DepoDur was not dosed according to age but rather by random assignment.

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These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.

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