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Case Reports   |    
Internalization of Bacteria by Osteoblasts in a Patient with Recurrent, Long-Term OsteomyelitisA Case Report
Michael J. Bosse, MD1; Helen E. Gruber, PhD1; Warren K. Ramp, PhD2
1 Department of Orthopaedic Surgery, Carolinas Medical Center, P.O. Box 32861, Charlotte, NC 28232. E-mail address for H.E. Gruber: helen.gruber@carolinashealthcare.org
2 Health Research Group, P.O. Box 146, Rockbridge Baths, VA 24473
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Investigation performed at the Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, North Carolina

The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 2005 Jun 01;87(6):1343-1347. doi: 10.2106/JBJS.D.02649
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Extract

Osteomyelitis, an infection of bone that can be acute, subacute, or chronic with sporadic recurrence, can result in prolonged and expensive treatment1,2. Treatment strategies, which usually depend on the stage of the disease at the time of diagnosis, often include débridement of the infected area, soft-tissue coverage, and subsequent long periods of antibiotic therapy. With the increasing development of antibiotic-resistant bacteria, antibiotic therapy has become even more problematic.
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    Accreditation Statement
    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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