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Sarcoidosis of the SpineA Report of Five Cases and a Review of the Literature
Bilal Boyaci, MD1; Francis Hornicek, MD, PhD2; Daniel Rosenthal, MD2; Henry Mankin, MD2; Frank X. Pedlow, Jr., MD2; Charles Carrier, BA2; Jurgen Harms, MD1; Andrew Rosenberg, MD2; Joseph Schwab, MD2
1 Department of Spine Surgery, SRH Klinikum Karlsbad-Langensteinbach, Guttmannstrasse 1, Karlsbad-Langensteinbach 76307, Germany
2 Department of Orthopedic Surgery (F.H., H.M., F.X.P., C.C., and J.S.), Department of Radiology (D.R.), and Department of Pathology and James Homer Wright Pathology Laboratories (A.R.), Massachusetts General Hospital, 55 Fruit Street, Yawkey 3, Boston, MA 02114. E-mail address for J. Schwab: jhschwab@partners.org
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Investigation performed at Massachusetts General Hospital, Boston, Massachusetts



Disclosure: None of the authors received payments or services, either directly or indirectly (i.e., via his or her institution), from a third party in support of any aspect of this work. None of the authors, or their institution(s), have had any financial relationship, in the thirty-six months prior to submission of this work, with any entity in the biomedical arena that could be perceived to influence or have the potential to influence what is written in this work. Also, no author has had any other relationships, or has engaged in any other activities, that could be perceived to influence or have the potential to influence what is written in this work. The complete Disclosures of Potential Conflicts of Interest submitted by authors are always provided with the online version of the article.

Copyright © 2012 by The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2012 Apr 04;94(7):e42 1-5. doi: 10.2106/JBJS.K.00062
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Extract

Sarcoidosis, also called Morbus Boeck disease, is a potentially systemic disease defined by noncaseating granulomatous inflammation of uncertain etiology1. The natural history of sarcoidosis is unpredictable as it can involve one or multiple organ systems and it can be progressive or resolve spontaneously. While sarcoidosis has been described as affecting most organ systems, the lungs are involved in >90% of cases2. Skeletal involvement is much less frequent; the prevalence has been reported to range from <1% to 13%2,3. The small bones of the hands and feet are most often involved, whereas spinal disease is rare4. Most patients with spinal sarcoidosis present with axial pain that resolves either on its own or after the administration of corticosteroids. However, pathologic fractures have been reported with associated neurologic sequelae5,6.
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    sarcoidosis ; spine

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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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