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STREPTOMYCIN IN TUBERCULOUS BONE AND JOINT LESIONS WITH MIXED INFECTION AND SINUSES
DAVID M. BOSWORTH; A. DELLA PIETRA; RICHARD F. FARRELL
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St. Luke's and Sea View Hospitals, and the House of St. Giles the Cripple, New York City
1950 by The American Orthopaedic Association, Inc.
J Bone Joint Surg Am, 1950 Jan 01;32(1):103-108
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Abstract

1. At the present time, streptomycin represents a tremendous advance in the treatment of patients with these lesions. Streptomycin undoubtedly will he improved upon and superseded by some other agent in the future, giving us better control of this disease and possibly enabling us to eradicate it.

2. In closed lesions streptomycin, in dosages of 90 grams in a period of ninety days, has failed to arrest the tuberculous process permanently.

3. Failure of treatment with streptomycin suggests strongly the presence of a sequestrum, a thick-walled abscess, or inadequate surgery.

4. Healing seems to be related to the duration of administration of streptomycin and not to the total dosage.

5. In patients having sinuses, streptomycin should be continued after healing for a period at least half as long as the healing period itself.

6. Surgical ankylosis, or resection of non-weight-bearing joints, is apparently as necessary now as it ever has been, but is much safer and more effective. Indeed, at times surgical attack is made possible only by the use of streptomycin.

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    Accreditation Statement
    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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