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EXPERIMENTAL INFARCTION OF BONE AND BONE MARROW Sequelae of Severance of the Nutrient Artery and Stripping of Periosteum
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Departments of Pathology and Orthopaedic Surgery of the Emory University School of Medicine, Emory University, Georgia; Laboratory Service and Section of Orthopaedic Surgery of Lawson Veterans Administration Hospital, Chamblee
1951 by The American Orthopaedic Association, Inc.
J Bone Joint Surg Am, 1951 Apr 01;33(2):396-406
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Cutting the nutrient vessels of the femur, together with stripping of its periosteum, was invariably followed by extensive infarction of bone and of bone marrow in young, rapidly growing rabbits. Impairment in the rate of circumferential growth accompanied cortical infarction, but no delay in longitudinal growth was found after infarction of enchondral bone. The cortical infarets in the bones of the animals of this series were almost completely repaired within two months except for changes in contour, whereas the Sequences of enchondral-bone formation became normal three weeks after the operation.

In ainimals approaching maturity, the operation produced varied results. Persistence of marrow infarcts for periods of five months or more accompanied ingrowths of fibrous tissue, and occasionally stimulated the production of one within the marrow compartment. Cortical infarcts in the bones of these animals were repaired so slowly that large amounsts of dead bone were present for as long as nine months after the initial injury.

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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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