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Case Reports   |    
Femoral Involvement by Langerhans Cell Histiocytosis Following Total Hip ArthroplastyA Case Report
Christine M. Pui, MD1; Harry E. Jergesen, MD2
1 Department of Orthopaedic Surgery, University of California, San Francisco, 500 Parnassus Avenue, MU-320W, San Francisco, CA 94143
2 Orthopaedic Trauma Institute, San Francisco General Hospital, 2550 23rd Street, Building 9, 2nd Floor, San Francisco, CA 94110. E-mail address: jergesen@orthosurg.ucsf.edu
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Disclosure: None of the authors received payments or services, either directly or indirectly (i.e., via his or her institution), from a third party in support of any aspect of this work. None of the authors, or their institution(s), have had any financial relationship, in the thirty-six months prior to submission of this work, with any entity in the biomedical arena that could be perceived to influence or have the potential to influence what is written in this work. Also, no author has had any other relationships, or has engaged in any other activities, that could be perceived to influence or have the potential to influence what is written in this work. The complete Disclosures of Potential Conflicts of Interest submitted by authors are always provided with the online version of the article.

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Investigation performed at the Department of Orthopaedic Surgery, University of California, San Francisco, California

Copyright © 2011 by The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2011 Sep 07;93(17):e98 1-6. doi: 10.2106/JBJS.K.00020
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Extract

Langerhans cell histiocytosis (LCH), formerly called "eosinophilic granuloma," is a benign bone neoplasm that is rare in adults. It is a cellular lesion with histiocytes, plasma cells, small lymphocytes, neutrophils, giant cells, foam cells, and eosinophilic leukocytes1. The disease typically presents during childhood, with >90% of cases occurring between the ages of five and fifteen years. LCH typically presents as a lytic medullary lesion with sharply defined margins, most commonly in the skull and in the diaphyses of long bones. The pelvis is affected in 5% to 17% of reported cases2,3.
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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