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Scientific Articles   |    
Subgroup Analyses: When Should We Believe Them?
Michelle Ghert, MD, FRCSC1; Brad Petrisor, MSc, MD, FRCSC1
1 Department of Surgery, McMaster University, 699 Concession Street, Hamilton, ON L8V 5C2, Canada. E-mail address for M. Ghert: michelle.ghert@jcc.hhsc.ca
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Disclosure: None of the authors received payments or services, either directly or indirectly (i.e., via his or her institution), from a third party in support of any aspect of this work. One or more of the authors, or his or her institution, has had a financial relationship, in the thirty-six months prior to submission of this work, with an entity in the biomedical arena that could be perceived to influence or have the potential to influence what is written in this work. No author has had any other relationships, or has engaged in any other activities, that could be perceived to influence or have the potential to influence what is written in this work. The complete Disclosures of Potential Conflicts of Interest submitted by authors are always provided with the online version of the article.

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Investigation performed at the Department of Surgery, McMaster University, Hamilton, Ontario, Canada


Copyright © 2012 by The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2012 Jul 18;94(Suppl 1(E)):61-64. doi: 10.2106/JBJS.L.00272
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You are an orthopaedic oncologist who has recently excised a high-grade soft-tissue sarcoma from the thigh of a fifty-year-old woman. This patient does not have metastatic disease, has had preoperative radiation, and is now in your clinic for her second postoperative visit. After some wound-healing issues, her wound is now healed and she would like to know if her chance of long-term survival would increase if she underwent adjuvant chemotherapy. Your sarcoma multidisciplinary team generally does not offer chemotherapy to patients with localized disease. However, you decide to consult the literature.
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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