You are an orthopaedic oncologist who has recently excised a high-grade soft-tissue sarcoma from the thigh of a fifty-year-old woman. This patient does not have metastatic disease, has had preoperative radiation, and is now in your clinic for her second postoperative visit. After some wound-healing issues, her wound is now healed and she would like to know if her chance of long-term survival would increase if she underwent adjuvant chemotherapy. Your sarcoma multidisciplinary team generally does not offer chemotherapy to patients with localized disease. However, you decide to consult the literature.