Journal Contents   |    
Léri's Pleonosteosis A Study of a Family with a Review of the Literature
John G. Rukavina; Harold F. Falls; John F. Holt; Walter D. Block
View Disclosures and Other Information
Departments of Dermatology and Syphilology, Ophthalmology, and Radiology, University of Michigan, Ann Arbor
1959 by The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 1959 Apr 01;41(3):397-408
5 Recommendations (Recommend) | 3 Comments | Saved by 3 Users Save Case


A study of a family in which features of a systemic disease were exhibited consistent with the diagnosis of Léri's pleonosteosis has been presented. It is believed to be the first North American family to be reported. The findings are those of a widespread constitutional disease which involves chiefly the connectivetissue system. The syndrome appears to be the consequence of a gene exhibiting an autosomal dominant mode of transmission. The gene presents good penetrance and a considerable variance in its range of expressivity. Certain ophthalmological, cutaneous, osseous, and roentgenographic findings present in the reported family and mentioned in the literature are considered as possibly being additional expressions of this pleiotropic syndrome. More necropsy material is needed with which to understand this important syndrome better.

Figures in this Article
    This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
    Sign In to Your Personal ProfileSign In To Access Full Content
    Not a Subscriber?
    Get online access for 30 days for $35
    New to JBJS?
    Sign up for a full subscription to both the print and online editions
    Register for a FREE limited account to get full access to all CME activities, to comment on public articles, or to sign up for alerts.
    Register for a FREE limited account to get full access to all CME activities
    Have a subscription to the print edition?
    Current subscribers to The Journal of Bone & Joint Surgery in either the print or quarterly DVD formats receive free online access to JBJS.org.
    Forgot your password?
    Enter your username and email address. We'll send you a reminder to the email address on record.

    Forgot your username or need assistance? Please contact customer service at subs@jbjs.org. If your access is provided
    by your institution, please contact you librarian or administrator for username and password information. Institutional
    administrators, to reset your institution's master username or password, please contact subs@jbjs.org


    Accreditation Statement
    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
    CME Activities Associated with This Article
    Submit a Comment
    Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
    Comments are moderated and will appear on the site at the discretion of JBJS editorial staff.

    * = Required Field
    (if multiple authors, separate names by comma)
    Example: John Doe

    Related Content
    The Journal of Bone & Joint Surgery
    JBJS Case Connector
    Related Audio and Videos
    Clinical Trials
    Readers of This Also Read...
    JBJS Jobs
    LA - Ochsner Health System
    OH - University Hospitals Case Medical Center
    IL - Hinsdale Orthopaedics
    CA - UCLA/OH Department of Orthopaedic Surgery