All cases of osteogenic sarcoma treated at the Massachusetts General Hospital during the forty-year period 1920 to 1960 were studied. Ninety-four patients fulfilled the diagnostic criteria of this study, and follow-up imiformation was obtained in ninety-two of the cases. Thirteen patients survived more than five years after surgical therapy.
The majority of the tumors were located imi the metaphyses of the bones having the greatest growth activity; that is, forty in the distal part of the femur, fourteen in the proximal part of the tibia, and ten in the proximal part of the humerus.
The tumors occurred most frequently during the period of active growth, forty-nine occurring in patients between the ages of fifteen and twenty-four years. Paget's disease was associated with osteogenic sarcoma in eleven patients, all of whom were over the age of forty.