Journal Contents   |    
Morquio's Disease and Dysplasia Epiphysalis Multiplex A Study of Epiphyseal Cartilage in Seven Cases
Carl E. Anderson; Jackson T. Crane; Harold A. Harper; T. Wesley Hunter
View Disclosures and Other Information
Departments of Orthopaedic Surgery and Pathology and Surgery, University of California School of Medicine, San Francisco
1962 by The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 1962 Mar 01;44(2):295-306
5 Recommendations (Recommend) | 3 Comments | Saved by 3 Users Save Case


The microscopic pathology of the epiphyseal cartilage plates and adjacent bone in seven patients with dwarfism and skeletal deformities has been reported. In two of the patients the clinical picture is clearly that of Morquio's syndrome; in two others, the picture resembles dysplasia epiphysalis multiplex; and in the remaining three there are some of the roentgenographic criteria of both of these conditions. Similar pathological changes were present in the epiphyseal cartilage plate in all seven cases. The essential defect is in the epiphyseal chondrocytes which fail to reach the zone of ossification in adequate numbers or in a fully developed hypertrophic condition, resulting in defective enchondral ossification. Deficient metaphyseal osteogenesis results from inadequate chondrocyte proliferation and maturation. Cystic amid mucoid degeneration of cartilage matrix and areas of aberrant epiphyseal ossification are also noted. None of the storage phenomena of Hurler's syndrome are present. The pathological findings in dysplasia epiphysalis multiplex, Morquio's disease, and achondroplasia relate directly to epiphyseal chondrocyte dysfunction. These conditions might therefore be grouped together under the term chondrogenic dwarfism to indicate their common pathological relationship. The epiphyseal cartilage changes in these coniditions are readily distinguished from those usually associated with dietary deficiencies and endocrine disorders in human subjects.

Figures in this Article
    This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
    Sign In to Your Personal ProfileSign In To Access Full Content
    Not a Subscriber?
    Get online access for 30 days for $35
    New to JBJS?
    Sign up for a full subscription to both the print and online editions
    Register for a FREE limited account to get full access to all CME activities, to comment on public articles, or to sign up for alerts.
    Register for a FREE limited account to get full access to all CME activities
    Have a subscription to the print edition?
    Current subscribers to The Journal of Bone & Joint Surgery in either the print or quarterly DVD formats receive free online access to JBJS.org.
    Forgot your password?
    Enter your username and email address. We'll send you a reminder to the email address on record.

    Forgot your username or need assistance? Please contact customer service at subs@jbjs.org. If your access is provided
    by your institution, please contact you librarian or administrator for username and password information. Institutional
    administrators, to reset your institution's master username or password, please contact subs@jbjs.org


    Accreditation Statement
    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
    CME Activities Associated with This Article
    Submit a Comment
    Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
    Comments are moderated and will appear on the site at the discretion of JBJS editorial staff.

    * = Required Field
    (if multiple authors, separate names by comma)
    Example: John Doe

    Related Content
    The Journal of Bone & Joint Surgery
    JBJS Case Connector
    Topic Collections
    Related Audio and Videos
    PubMed Articles
    Clinical Trials
    Readers of This Also Read...
    JBJS Jobs
    New York - Icahn School of Medicine at Mount Sinai
    District of Columbia (DC) - Children's National Medical Center
    W. Virginia - Charleston Area Medical Center
    S. Carolina - Department of Orthopaedic Surgery Medical Univerity of South Carlonina