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Ultrastructure of Articular Cartilage of Mice Treated with Somatotrophin
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From the Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, and the Histopathological Institute of the University of Zürich, Zürich, Switzerland
1964 by The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 1964 Jun 01;46(4):766-780
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Administration of somatotropic hormone to newborn or weanling mice of strain C57BL Jax6 for one, two, or four weeks accelerated articular growth and development. The organelles were increased in number and the appearance of granular endoplasmic reticulum, Golgi vacuoles, multivesicular bodies, and glycogen was hastened. Toward the end of the developmental cycle, the chondrocytes swelled excessively and their plasmalemma ruptured without evidence of vascular erosion. After four weeks of treatment, there was premature breakdown of chondrocytes, their place being taken by fibrillar microscars. In the matrix, development of fibers was accentuated. The intensification of fibrillarity was followed by disorientation of the superficial collagen fibers with fraying of the articular covering. The functional significance of these findings, as well as their relation to aging changes in cartilage, is discussed.

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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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