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Atypical Femoral Fractures: What Do We Know About Them?AAOS Exhibit Selection
Aasis Unnanuntana, MD1; Anas Saleh, MD2; Kofi A. Mensah, MD, PhD2; John P. Kleimeyer, BA3; Joseph M. Lane, MD2
1 Department of Orthopaedic Surgery, Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkoknoi District, Bangkok 10700, Thailand. E-mail address: uaasis@gmail.com
2 Department of Orthopaedic Surgery, Hospital for Special Surgery, 523 East 72nd Street, New York, NY 10021
3 Weill Cornell Medical College, Cornell University, 1300 York Avenue, New York, NY 10065
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Investigation performed at Siriraj Hospital, Mahidol University, Bangkok, Thailand, and the Hospital for Special Surgery, New York, NY

Disclosure: None of the authors received payments or services, either directly or indirectly (i.e., via his or her institution), from a third party in support of any aspect of this work. One or more of the authors, or his or her institution, has had a financial relationship, in the thirty-six months prior to submission of this work, with an entity in the biomedical arena that could be perceived to influence or have the potential to influence what is written in this work. No author has had any other relationships, or has engaged in any other activities, that could be perceived to influence or have the potential to influence what is written in this work. The complete Disclosures of Potential Conflicts of Interest submitted by authors are always provided with the online version of the article.

Copyright © 2013 by The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2013 Jan 16;95(2):e8 1-13. doi: 10.2106/JBJS.L.00568
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Bisphosphonates are the most commonly prescribed type of medication for the treatment of osteoporosis. Studies have shown that bisphosphonates reduce the incidence of vertebral and nonvertebral fractures when used to treat postmenopausal osteoporosis1-4. The indications for use of bisphosphonates also extend to other metabolic bone diseases such as glucocorticoid-induced osteoporosis, Paget disease, hypercalcemia due to a variety of causes, and skeletal metastases5-7. Treatment with bisphosphonates, however, is not without adverse effects. Because bisphosphonates act by inhibiting osteoclast function and inducing osteoclast apoptosis8,9, there is a substantial concern regarding the potential side effects related to severe suppression of the bone turnover rate.
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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