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Age-Related Variations in Proteinpolysaccharides from Human Nucleus Pulposus, Annulus Fibrosus, and Costal Cartilage
WALTER E. GOWER; VITTORIO PEDRINI
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From the Department of Orthopedic Surgery, University of Iowa, Iowa City
1969 by The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 1969 Sep 01;51(6):1154-1162
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Abstract

Light fraction proteinpolysaccharide was prepared by water extraction of nucleus pulposus, annulus fibrosus, and costal cartilage obtained at autopsy from fifteen skeletally normal subjects ranging in age from four and one half to seventy-six years. Age dependent changes in glucosamine and galactosamine content of the crude tissue and of the light fraction proteinpolysaccharide were demonstrated. A decrease with aging in per cent of total hexosamine extractable in the light fraction proteinpolysaccharide and an increase in protein content was observed in all three tissues. Electrophoresis of the light fraction produced two main components differing in both polysaccharide and protein content.

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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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