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Uridine Diphosphate (UDP) Stimulation of Protein Polysaccharide Production A PRELIMINARY REPORT
MICHAEL G. EHRLICH; HENRY J. MANKIN; BENJAMIN V. TREADWELL; HARDIN JONES
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From the Departments of Orthopaedics of the Massachusetts General Hospital and Harvard Medical School, Boston, and the Hospital for Joint Diseases and Mount Sinai School of Medicine of the City University of New York
1974 by The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 1974 Sep 01;56(6):1239-1245
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Abstract

Uridine diphosphate, at a concentration of one millimole per milliliter, was found to stimulate the rate of incorporation of 35SO4 and 3H-glycine into articular cartilage both in vivo and in vitro. These findings suggest that uridine diphosphate somehow acts to increase proteoglycan synthesis by the chondrocyte. The mechanism of action is obscure, but the data suggest that uridine diphosphate may act as a stimulator of ribonucleic acid synthesis.

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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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