To determine possible deleterious effects of methylmethacrylate vapor on
mouse gestation, pregnant mice were exposed to average vapor concentrations
of 1330 parts per million for two hours twice daily during Day 6 through
Day 15 of pregnancy. A slight increase in the average weight of the fetuses
of the exposed mothers were demonstrated but no other evidence of fetal
toxicity or teratologic effects was found. During three total hip
replacements, the concentration of methylmethacrylate in operating-room air
never rose above 280 parts per million.