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Instructional Course Lecture   |    
Bacterial Biofilms and Periprosthetic Infections
William V. Arnold, MD, PhD1; Mark E. Shirtliff, PhD2; Paul Stoodley, PhD3
1 The Rothman Institute, 925 Chestnut Street, Philadelphia, PA 19107. E-mail address: balec.arnold@comcast.net
2 Department of Microbiology and Immunology, School of Medicine, University of Maryland-Baltimore, Room #9209 - 650 West Baltimore Street, Baltimore, MD 21201
3 Departments of Microbial Infection and Immunity and Orthopedics, Center for Microbial Interface Biology, 716 Biomedical Research Tower, The Ohio State University, 460 West 12th Avenue, Columbus, OH 43210
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An Instructional Course Lecture, American Academy of Orthopaedic Surgeons

Printed with permission of the American Academy of Orthopaedic Surgeons. This article, as well as other lectures presented at the Academy’s Annual Meeting, will be available in March 2014 in Instructional Course Lectures, Volume 63. The complete volume can be ordered online atwww.aaos.org, or by calling 800-626-6726 (8 a.m.-5 p.m., Central time).



Disclosure: None of the authors received payments or services, either directly or indirectly (i.e., via his or her institution), from a third party in support of any aspect of this work. None of the authors, or their institution(s), have had any financial relationship, in the thirty-six months prior to submission of this work, with any entity in the biomedical arena that could be perceived to influence or have the potential to influence what is written in this work. Also, no author has had any other relationships, or has engaged in any other activities, that could be perceived to influence or have the potential to influence what is written in this work. The complete Disclosures of Potential Conflicts of Interest submitted by authors are always provided with the online version of the article.

Copyright © 2013 by The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2013 Dec 18;95(24):2223-2229
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Extract

The diagnosis and treatment of periprosthetic infection after joint arthroplasty is often frustrating for the orthopaedic surgeon. The application of certain diagnostic criteria and different treatment strategies can be better directed if these infections are placed in the context of microbial biofilms. An understanding of this biofilm mode of microbial infection can help to explain the phenomenon of culture-negative infection as well as provide an understanding of why certain treatment modalities often fail. Continued basic research into the role of biofilms in infection will likely provide improved strategies for the clinical diagnosis and treatment of periprosthetic infection.
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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