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Spontaneous Osteonecrosis of the Knee Treated with Autologous Chondrocyte Implantation, Autologous Bone-Grafting, and OsteotomyA Report of Two Cases with Follow-up of Seven and Nine Years
Arvind von Keudell, MD1; Andreas H. Gomoll, MD1; Tim Bryant, RN1; Tom Minas, MD, MS1
1 Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, 850 Boylston Street, Suite 112, Chestnut Hill, MA 02467. E-mail address for T. Minas: tminas@partners.org
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Disclosure: None of the authors received payments or services, either directly or indirectly (i.e., via his or her institution), from a third party in support of any aspect of this work. One or more of the authors, or his or her institution, has had a financial relationship, in the thirty-six months prior to submission of this work, with an entity in the biomedical arena that could be perceived to influence or have the potential to influence what is written in this work. Also, one or more of the authors has had another relationship, or has engaged in another activity, that could be perceived to influence or have the potential to influence what is written in this work. The complete Disclosures of Potential Conflicts of Interest submitted by authors are always provided with the online version of the article.

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Investigation performed at Brigham and Women's Hospital, Chestnut Hill, Massachusetts

Copyright © 2011 by The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2011 Dec 21;93(24):e149 1-7. doi: 10.2106/JBJS.K.00242
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Extract

Spontaneous osteonecrosis of the knee is a disease whose primary etiology remains unknown. First described by Ahlbäck et al.1 in 1968, it is now categorized as either primary (spontaneous) or secondary osteonecrosis2. Primary osteonecrosis usually presents in people over the age of fifty years, with sudden onset of pain, most frequently in the medial femoral condyle. Secondary osteonecrosis is associated with certain risk factors, such as corticosteroid therapy and alcohol use, and is usually encountered in younger people.
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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