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Bone-Marrow Transplantation in Sickle-Cell Disease. Effect on Osteonecrosis: A Case Report with a Four-Year Follow-up*
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Investigation performed at Hôpital Henri Mondor, Creteil
J Bone Joint Surg Am, 1997 Nov 01;79(11):1726-30
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Sickle-cell disease involves both hematological and osseous abnormalities because it affects the two major functions of bone tissue: hematopoiesis and osteogenesis. Symptoms include dactylitis, painful vaso-occlusive crises, splenic reticuloendothelial dysfunction (also called functional asplenia), and multiple-organ damage and failure in children and adults. It is probably the most common cause of avascular necrosis worldwide5; in series of adult patients, the reported prevalence of involvement of the femoral head was 30 per cent (ninety-five of 320 hips)13 and that of the humeral head was 48 per cent (106 of 220 shoulders)11.
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