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Current Concepts Review   |    
Current Concepts Review - Hemihypertrophy. Concepts and Controversies*
R. TRACY BALLOCK, M.D.†; GEORGIA L. WIESNER, M.D.†; MELISSA T. MYERS, M.D.†; GEORGE H. THOMPSON, M.D.†, CLEVELAND, OHIO
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Investigation performed at Case Western Reserve University, Rainbow Babies and Childrens Hospital, University Hospitals of Cleveland, Cleveland
J Bone Joint Surg Am, 1997 Nov 01;79(11):1731-8
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Hemihypertrophy is best defined as asymmetry between the right and left sides of the body to a greater degree than can be attributed to normal variation. This asymmetry often appears as a difference in the size or length of the extremities, but it may also involve the head, trunk, and internal organs. It is often extremely difficult to distinguish hemihypertrophy from normal variation. However, this distinction is very important because young children who have hemihypertrophy are at increased risk of malignant intra-abdominal tumors, such as Wilms tumor or hepatoblastoma9,21,22,24,27,29,31,47,60. The increased risk of neoplasia has led to the controversial recommendation of frequent abdominal ultrasound screening designed to detect the tumor at the earliest possible stage2,12,16,25.
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