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Sclerotic Lesion of the Tibia without Involvement of Lymph Nodes. Report of an Unusual Case of Rosai-Dorfman Disease*
FRANCIS R. PATTERSON, M.D.†; MICHELE T. ROONEY, M.D.†; TIMOTHY A. DAMRON, M.D.†; ANDREI I. VERMONT, M.D.†; ROBERT E. HUTCHISON, M.D.†, SYRACUSE, NEW YORK
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Investigation performed at the Departments of Orthopedic Surgery, Pathology, and Radiology, State University of New York Health Science Center, Syracuse
J Bone Joint Surg Am, 1997 Jun 01;79(6):911-6
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Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy, was first described in 1969 and is characterized by widespread adenopathy, fever, leukocytosis, an elevated sedimentation rate, and hypergammaglobulinemia12,13. Since 1969, extranodal involvement has been noted in 182 of the 423 patients in the registry of Rosai-Dorfman disease2,16. Osseous involvement is typically lytic and was observed in thirty-three of the 423 patients in the registry2. We report on a patient who was first seen because of symptoms due to a predominately sclerotic tibial lesion but who had no evidence of lymphadenopathy, a characteristic of Rosai-Dorfman disease.
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