0
Articles   |    
Mycobacterium bovis Osteomyelitis as a Complication of Bacille Calmette-Guérin (BCG) Vaccination: Rapid Diagnosis with Use of DNA Sequencing Analysis. A Case Report*
CHII-JENG LIN, M.D., PH.D.†; WANG-SHENG YANG, M.D.‡; JING-JOU YAN, M.D.†; CHING-CHUAN LIU, M.D.†, TAINAN, TAIWAN
View Disclosures and Other Information
Investigation performed at National Cheng Kung University Medical College, Tainan
J Bone Joint Surg Am, 1999 Sep 01;81(9):1305-11
5 Recommendations (Recommend) | 3 Comments | Saved by 3 Users Save Case

Extract

Vaccination with bacille Calmette-Guérin (BCG) has been used for the prevention of tuberculosis in many areas of the world. It is estimated that more than three billion people worldwide have been vaccinated with live BCG since 19459. In almost all children, inoculation with BCG is harmless. However, it must be understood that BCG, like other vaccines, such as that for poliomyelitis and even that for measles, mumps, and rubella, occasionally produces adverse reactions5,11,21-23. Despite these rare complications, BCG has proved to be effective for preventing miliary tuberculosis and tubercular meningitis in many developing countries. Disseminated complications were observed in association with approximately one per million vaccinations, and severe local reactions occurred in approximately 2 percent of individuals who were vaccinated11,22,23. BCG osteomyelitis has been reported often in Europe but relatively rarely elsewhere1-3,6,7,13,25; however, it may not be as rare as it seems. It is possible that the diagnosis may be missed unless the treating physician has a high index of suspicion and unless a sensitive technique of identification is available. This complication deserves greater attention because it has been reported in association with intravesical administration of BCG for the treatment of carcinoma of the bladder8,24.
Figures in this Article

    First Page Preview

    View Large
    />
    First page PDF preview
    Sign In to Your Personal ProfileSign In To Access Full Content
    Not a Subscriber?
    Get online access for 30 days for $35
    New to JBJS?
    Sign up for a full subscription to both the print and online editions
    Register for a FREE limited account to get full access to all CME activities, to comment on public articles, or to sign up for alerts.
    Register for a FREE limited account to get full access to all CME activities
    Have a subscription to the print edition?
    Current subscribers to The Journal of Bone & Joint Surgery in either the print or quarterly DVD formats receive free online access to JBJS.org.
    Forgot your password?
    Enter your username and email address. We'll send you a reminder to the email address on record.

     
    Forgot your username or need assistance? Please contact customer service at subs@jbjs.org. If your access is provided
    by your institution, please contact you librarian or administrator for username and password information. Institutional
    administrators, to reset your institution's master username or password, please contact subs@jbjs.org

    References

    Accreditation Statement
    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
    CME Activities Associated with This Article
    Submit a Comment
    Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
    Comments are moderated and will appear on the site at the discretion of JBJS editorial staff.

    * = Required Field
    (if multiple authors, separate names by comma)
    Example: John Doe





    Related Content
    The Journal of Bone & Joint Surgery
    JBJS Case Connector
    Topic Collections
    Related Audio and Videos
    PubMed Articles
    Clinical Trials
    Readers of This Also Read...
    JBJS Jobs
    12/31/2013
    SC - Department of Orthopaedic Surgery Medical Univerity of South Carlonina
    05/03/2012
    CA - UCLA/OH Department of Orthopaedic Surgery
    03/05/2014
    OK - The University of Oklahoma