Markus J. Seibel, Simon P. Robins, and John P. Bilezikian,
editors. San Diego: Academic Press; 1999. 672 pages. $149.95.
This book represents the combined expertise of many of the world
leaders in addressing the metabolic and biological aspects of bone
and cartilage. The strengths of this book rest with the clear knowledge
base of the chapter authors, the breadth of the subject matter,
and the consideration of a vast amount of information. The book
brings the reader up-to-date in a rapidly changing field.
The book is divided into three sections. The first section covers
the components of the organic extracellular matrix of bone and cartilage
and includes a detailed discussion of collagen and growth factors. The
second section is devoted to the structure and metabolism of the
extracellular matrix, including the cells and the matrix and hormones
regulating bone and cartilage. The third section addresses markers
of bone and cartilage metabolism in normal individuals and in those
who have common diseases, such as osteoporosis, osteomalacia, rheumatoid
arthritis, osteoarthritis, and growth disorders. The Basic Science
book and the Orthopaedic Knowledge Updates produced by the American
Academy of Orthopaedic Surgeons contain only brief mention of the
underlying pathophysiology of bone and cartilage diseases, whereas the
current book offers a broad discussion of the full pathophysiology
of common musculoskeletal disorders.
This book is largely written by bone and cartilage physiologists
and endocrinologists. The coverage of metabolic and biological issues
is superb. The book does lack a clear integration with regard to biomechanical
influences; this aspect should be sought elsewhere. It also offers
little information on treatment.
The subject matter and the timely, extensive bibliography are
good starting points for orthopaedists who want to delve into the
pathophysiology of common bone and cartilage disorders. Authors
of introductory remarks for articles on these subjects, including
articles in peer-reviewed orthopaedic journals, would benefit from
a survey of the book’s pertinent chapters. Clinicians eager
to upgrade their understanding of the various new clinical methods for
defining and evaluating bone and cartilage disorders will find a
treasure trove of information to help them to steer through the
complex array of choices.
In summary, this is a valuable and unique addition that will
help the musculoskeletal specialist to understand the metabolism
and pathophysiology of bone and cartilage in health and disease.
It will be most useful as a reference source to be consulted on a "need
to know" basis as clinical questions arise. This book should
reside in the libraries of hospitals, residency programs, and large
group practices.