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The Risk of Cancer Following Total Hip or Knee Arthroplasty
Ravi Tharani, BS; Frederick J. Dorey, PhD; Thomas P. Schmalzried, MD
J Bone Joint Surg Am, 2001 May 01;83(5):774-780
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Extract

The first well-documented case of cancer associated with total joint replacement was in a patient in whom a malignant fibrous histiocytoma developed three and one-half years after a McKee-Farrar total hip replacement that was performed in December 19691. At least twenty-four additional cases of malignant disease occurring in association with a total hip or knee prosthesis have been reported in the English-language literature2-20. On the basis of this small number of case reports, there is no apparent relationship between any specific implanted material and cancer.
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