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Pulmonary Dysfunction in Patients with Femoral Shaft Fracture Treated with Intramedullary Nailing
Brent L. Norris, MD; W. Christopher Patton, MD; Joseph N. Rudd, Jr, BSNPhD; Colleen M. Schmitt, MD, MHS; Jeffrey A. Kline, MD
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Investigation performed at the University of Tennessee College of Medicine, Chattanooga, Tennessee, and the Carolinas Medical Center, Charlotte, North Carolina
Brent L. Norris, MD
Joseph N. Rudd Jr., BSN, PhD
Department of Orthopaedic Surgery, University of Tennessee College of Medicine, Chattanooga Unit, 975 East Third Street, Box 287, Chattanooga, TN 37403. E-mail address for B.L. Norris: norrisbl@erlanger.org

W. Christopher Patton, MD
Alabama Orthopaedic Clinic, 271 Azalea Road, Mobile, AL 36609. E-mail address: wcpattonmd@aol.com

Colleen M. Schmitt, MD, MHS
Department of Internal Medicine, University of Tennessee College of Medicine, Chattanooga Unit, 975 East Third Street, Suite 505, Chattanooga, TN 37403

Jeffrey A. Kline, MD
Department of Emergency Medicine, Carolinas Medical Center, MEB 304, 1000 Blythe Boulevard, Charlotte, NC 28232-2861

No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article. Funds were received in total or partial support of the research or clinical study presented in this article. The funding sources were a Charlotte-Mecklenburg Hospital Authority Grant and the Chattanooga Orthopaedic Educational Research Foundation.

J Bone Joint Surg Am, 2001 Aug 01;83(8):1162-1168
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Background: This study was undertaken to determine whether alveolar dead space increases during intramedullary nailing of femoral shaft fractures and whether alveolar dead space predicts postoperative pulmonary dysfunction in patients undergoing intramedullary nailing of a femoral shaft fracture.

Methods: All patients with a femoral shaft fracture were prospectively enrolled in the study unless there was evidence of acute myocardial infarction, shock, or heart failure. Arterial blood gases were measured at three consecutive time-periods after induction of general anesthesia: before intramedullary nailing and ten and thirty minutes after intramedullary nailing. The end-tidal carbon-dioxide level, minute ventilation, positive end-expiratory pressure, and percent of inspired and expired inhalation agent were recorded simultaneously with the blood-gas measurement. Postoperatively, all subjects were monitored for evidence of pulmonary dysfunction, defined as the need for mechanical ventilation or supplemental oxygen (at a fraction of inspired oxygen of >40%) in the presence of clinical signs of a respiratory rate of >20 breaths/min or the use of accessory muscles of respiration.

Results: Seventy-four patients with a total of eighty femoral shaft fractures completed the study. Fifty fractures (62.5%) underwent nailing after reaming, and thirty fractures (37.5%) underwent nailing with minimal or no reaming. The mean alveolar dead-space measurements before canal opening and at ten and thirty minutes after canal opening were 14.5%, 15.8%, and 15.2% in the total series of seventy-four patients (general linear model, p = 0.2) and 20.5%, 22.7%, and 24.2% in the twenty patients with postoperative pulmonary dysfunction (general linear model, p = 0.05). Of the twenty-one patients with an alveolar dead-space measurement of >20% thirty minutes after nailing, sixteen had postoperative pulmonary dysfunction. According to univariate and multivariate analysis, the alveolar dead-space measurement was strongly associated with postoperative pulmonary dysfunction.

Conclusions: According to our data, intramedullary nailing of femoral shaft fractures did not significantly increase alveolar dead space, and the amount of alveolar dead space can predict which patients will have pulmonary dysfunction postoperatively.

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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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