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The Orthopaedic Genome: What Does the Future Hold and Are We Ready?
J. Edward Puzas, PhD; Regis J. O'Keefe, MD, PhD; Jay R. Lieberman, MD
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J. Edward Puzas, PhD
Regis J. O’Keefe, MD, PhD
Department of Orthopaedics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 655, Rochester, NY 14642

Jay R. Lieberman, MD
Department of Orthopaedics, University of California at Los Angeles Medical Center, 10833 Le Conte Avenue, Los Angeles, CA 90095

Read at the Annual Meeting of the American Orthopaedic Association, Palm Beach, Florida, June 14, 2001

The authors did not receive grants or outside funding in support of their research or preparation of this manuscript. They did not receive payments or other benefits or a commitment or ageement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.

Presented at the Annual Meeting of the American Orthopaedic Association, Palm Beach, Florida, June 13-16, 2001.

J Bone Joint Surg Am, 2002 Jan 01;84(1):133-141
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The course of biomedical research and the practice of modern medicine have crossed into a new frontier—that of molecular genetics. The sequencing of the human genome will forever change the way that we view disease, and, in many cases, will point the way toward cures for diseases that we have not yet characterized. The disciplines of musculoskeletal research and clinical orthopaedics are part of this revolution. The following discussion highlights some of the recent advances in molecular and genetic biology, describes their possible application to the care of orthopaedic patients, and presents some of the social and ethical issues associated with the use of gene-altering therapy in humans.
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