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Hip Prosthesis of Antibiotic-Loaded Acrylic Cement for the Treatment of Infections Following Total Hip Arthroplasty
Steven J. Wentworth, BS; Bassam A. Masri, MD; Clive P. Duncan, MD; Carleton B. Southworth, BA, MS
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Corresponding author:
Bassam A. Masri, MD
Department of Orthopaedics, Vancouver Hospital and Health Sciences Center, University of British Columbia, Vancouver, British Columbia, Canada, V5Z4E1. E-mail address for B. Masri: masri@interchange.ubc.ca

The authors did not receive grants or outside funding in support of their research or preparation of this manuscript. One or more of the authors received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity (DePuy). No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.

J Bone Joint Surg Am, 2002 Nov 01;84(suppl 2):S123-S128
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Infection continues to be one of the most feared complications of total hip arthroplasty. Despite many advances over the past three decades, this infrequent complication continues to undermine an otherwise highly predictable and successful procedure. The prosthesis of antibiotic-loaded acrylic cement (PROSTALAC; DePuy, Warsaw, Indiana) is a temporary hip-replacement articulated spacer intended for patients who need a two-stage exchange arthroplasty for the treatment of a confirmed or suspected infection at the site of a total hip replacement. This device has received approval from the United States Food and Drug Administration as a humanitarian use device. (This humanitarian device has been authorized by federal law as a short-term total hip replacement [THR] in patients who need a two-stage procedure to treat a confirmed infection of their THR and where vancomycin and tobramycin are the most appropriate antibiotics for treatment of the infection based on the susceptibility pattern of the infecting microorganism[s]. The effectiveness of this device for this use has not been determined.) The early experience with 135 patients who were treated with the PROSTALAC implant is reported. Initial experience has also been reported in previous publications 1-2 .
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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