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Evidence-Based Orthopaedics   |    
Autologous Chondrocyte Implantation Was Superior to Mosaicplasty for Repair of Articular Cartilage Defects in the Knee at One Year

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For correspondence: Professor G. Bentley, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, United Kingdom
Source of funding: Not stated.
Bentley G, Biant LC, Carrington RWJ, Akmal M, Goldberg A, Williams AM, Skinner JA, Pringle J. A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee.
J Bone Joint Surg Br
. 2003 Mar;85: 223-30.

The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 2003 Nov 01;85(11):2259-2259
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Question: In patients with articular cartilage defects in the knee, how effective is autologous chondrocyte implantation (ACI) compared with mosaicplasty?Design: Randomized (unclear allocation concealment), unblinded, controlled trial with clinical and arthroscopic assessment at 1 year.Setting: A hospital in Middlesex, United Kingdom.Patients: 100 patients (mean age, 31.3 years; 57% men) with a symptomatic lesion of the articular cartilage in the knee (mean size of the defect, 4.66 cm2) and persistent pain and reduction in activities. The mean duration of symptoms was 7.2 years, and 94 patients had had previous surgical intervention. Follow-up was complete.
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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