Question: In patients with articular cartilage defects in the knee,
how effective is autologous chondrocyte implantation (ACI) compared with
mosaicplasty?Design: Randomized (unclear allocation concealment), unblinded,
controlled trial with clinical and arthroscopic assessment at 1 year.Setting: A hospital in Middlesex, United Kingdom.Patients: 100 patients (mean age, 31.3 years; 57% men) with a
symptomatic lesion of the articular cartilage in the knee (mean size of the
defect, 4.66 cm2) and persistent pain and reduction in activities.
The mean duration of symptoms was 7.2 years, and 94 patients had had previous
surgical intervention. Follow-up was complete.