Scientific Article   |    
Factors Affecting the Durability of Primary Total Knee Prostheses
James A. Rand, MD; Robert T. Trousdale, MD; Duane M. Ilstrup, MS; W. Scott Harmsen, MS
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Investigation performed at the Department of Orthopedic Surgery and Department of Biostatistics, Mayo Clinic, Rochester, Minnesota

James A. Rand, MD
Department of Orthopedic Surgery, Mayo Clinic Scottsdale, 13400 East Shea Boulevard, Scottsdale, AZ 85259. E-mail address: rand.james@mayo.edu

Robert T. Trousdale, MD
Duane M. Ilstrup, MS
W. Scott Harmsen, MS
Mayo Clinic Rochester, 200 First Street S.W., Rochester, Minnesota 55905

The authors did not receive grants or outside funding in support of their research or preparation of this manuscript. One or more of the authors received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity (royalties from Smith and Nephew). In addition, a commercial entity (Smith and Nephew) paid or directed, or agreed to pay or direct, benefits to a research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.

J Bone Joint Surg Am, 2003 Feb 01;85(2):259-265
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Background: Failure of total knee arthroplasty is problematic. The purpose of this study was to evaluate the factors that influence the durability of a primary total knee prosthesis.

Methods: A survivorship analysis of 11,606 primary total knee arthroplasties carried out between January 1, 1978, and December 31, 2000, was performed. An analysis of patient and implant-related factors affecting survivorship was done with use of a multivariate Cox model.

Results: The survivorship was 91% (95% confidence interval, 90% to 91%) at ten years (2943 knees), 84% (95% confidence interval, 82% to 86%) at fifteen years (595 knees), and 78% (95% confidence interval, 74% to 81%) at twenty years (104 knees) following the surgery. Prosthetic survivorship at ten years was 83% for patients fifty-five years of age or less compared with 94% for those older than seventy years of age (p < 0.0001), 90% for those with a diagnosis of osteoarthritis compared with 95% for those with inflammatory arthritis (p < 0.005), and 91% for those with retention of the posterior cruciate ligament compared with 76% for those with substitution of the posterior cruciate ligament (a posterior stabilized prosthesis) (p < 0.0001). Survivorship at ten years was 92% for nonmodular metal-backed tibial components, 90% for modular metal-backed tibial components, and 97% for all-polyethylene tibial components (p < 0.0001). Survivorship at ten years was 92% for prostheses fixed with cement compared with 61% for those fixed without cement (p < 0.0001).

Conclusions: Significant risk factors for failure of total knee arthroplasty were the type of implant, age and gender of the patient, diagnosis, type of fixation, and design of the patellar component. In the ideal situation—treatment of a woman over the age of seventy years who has inflammatory arthritis with a nonmodular, metal-backed tibial component, cement fixation, an all-polyethylene patellar component, and retention of the posterior cruciate ligament—the ten-year survivorship of the prosthesis was estimated to be 98% (95% confidence interval, 97% to 99%).

Level of Evidence: Prognostic study, Level II-1 (retrospective study). See Instructions to Authors for a complete description of levels of evidence.

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    Accreditation Statement
    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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