Introduction   |    
Introductory Comments
Lawrence C. Rosenberg, MD
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Deputy Editor for Research, The Journal of Bone and Joint Surgery

J Bone Joint Surg Am, 2003 Aug 01;85(suppl 3):1-2
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This supplement to The Journal of Bone and Joint Surgery consists of articles based on presentations delivered at the Fourth International Conference on Bone Morphogenetic Proteins, held in Sacramento, California, in October 2002. Many of these articles, particularly those on the clinical applications of recombinant human bone morphogenetic proteins (rhBMPs), will be of special interest to orthopaedic surgeons. For example, Einhorn 1 summarizes the results of prospective, randomized clinical trials of the use of rhBMPs in the treatment of tibial nonunions and open tibial shaft fractures. On the basis of the results of the tibial nonunion study 2 , the United States Food and Drug Administration has issued a Humanitarian Device Exemption for the use of an OP-1 (rhBMP-7) implant as "an alternative to the patient's own bone (autograft) in recalcitrant long bone nonunions where autograft is unfeasible and alternative treatments have failed." 3
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    Accreditation Statement
    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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