During the last decade, phenomenal discoveries have been made in molecular
biology, and powerful new methods have been developed for elucidating the role
of abnormalities in gene expression in the pathogenesis of human diseases.
Scientists have appreciated the implications of these new developments. They
understand that we have entered a new era in biomedical research, and they
have applied this new knowledge and methodology in diverse areas of
orthopaedic research, particularly to studies of the biologic processes that
are involved in the formation of cartilage and bone during development and in
the repair of bone in the adult.