Evidence-Based Orthopaedics   |    
Olpadronate Reduced Fractures in Children with Osteogenesis Imperfecta

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Sources of funding: No external funding.
For correspondence: R. Sakkers, Department of Orthopaedic Surgery, KE 4.140.5, Wilhelmina Children's Hospital, University Medical Centre Utrecht, P.O. Box 85090, 3508 AB Utrecht, The Netherlands. E-mail: r.sakkers@wkz.azu.nl
Sakkers R, Kok D, Engelbert R, van Dongen A, Jansen M, Pruijs H, Verbout A, Schweitzer D, Uiterwaal C. Skeletal Effects and Functional Outcome with Olpadronate in Children with Osteogenesis Imperfecta: A 2-Year Randomised Placebo-Controlled Study.
. 2004 May 1;363:1427-31.

The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 2004 Nov 01;86(11):2575-2575
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Question: In children with osteogenesis imperfecta, is daily olpadronate therapy better than placebo in reducing fractures?Design: Randomized (allocation concealed), blinded (clinicians, patients, and outcome assessors), placebo-controlled trial with 2-year follow-up.Setting: A university medical center in Utrecht, The Netherlands.Patients: 34 children, 3 to 18 years of age (mean age, 10 y, 53% girls), with osteogenesis imperfecta with restricted ambulation (maximum walking distance, 250 m). Follow-up was complete.
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