Evidence-Based Orthopaedics   |    
Aprotinin Reduced Blood Loss in Long-Segment Posterior Spinal Fusion

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Source of funding: Orthopaedic Research and Education Foundation.
For correspondence: J.W. Cole, Department of Anesthesiology, Division of Pediatric Anesthesiology, Washington University School of Medicine, St. Louis Children's Hospital, One Children's Place, St. Louis, MO 63110. E-mail: colejw@msnotes.wustl.edu
Cole JW, Murray DJ, Snider RJ, Bassett GS, Bridwell KH, Lenke LG. Aprotinin Reduces Blood Loss During Spinal Surgery in Children.
2003 Nov 1;28: 2482-5.

The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 2004 May 01;86(5):1102-1102
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Question:In children undergoing long-segment posterior spinal fusion, does the use of aprotinin reduce blood loss?Design: Randomized (unclear allocation concealment), blinded (clinicians and patients), placebo-controlled trial with follow-up to discharge.Setting: 2 children's hospitals in St. Louis, Missouri.Patients: 44 children and adolescents (mean age, 13 yr) who required long-segment posterior spinal fusion (=7 segments) for spinal deformities and who were at high risk for blood loss because of neuromuscular scoliosis or an underlying medical condition or because the procedure was a reoperation. Follow-up was complete.
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