0
The Orthopaedic Forum   |    
Large Clinical Trials in Musculoskeletal Trauma: Are They Possible?Lessons Learned from the International Study of the Use of Rhbmp-2 in Open Tibial Fractures
Cristina Csimma, RPh, MHP1; Marc F. Swiontkowski, MD2
1 Wyeth Research, 87 Cambridge Park Drive, Office 3013, Cambridge, MA 02140. E-mail address: ccsimma@wyeth.com
2 Department of Orthopaedic Surgery, University of Minnesota, 2450 Riverside Avenue, Room 200, Minneapolis, MN 55454. E-mail address: swion001@umn.edu
View Disclosures and Other Information
One author (C.C.) is an employee of Wyeth Research. In addition, one author (M.F.S.) received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity (a consulting agreement for study design). No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.

The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 2005 Jan 01;87(1):218-222. doi: 10.2106/JBJS.D.01938
5 Recommendations (Recommend) | 3 Comments | Saved by 3 Users Save Case

Extract

As a result of medical complexity and urgent care needs, the trauma patient population has not been considered conducive to study with use of traditional clinical trial designs. Efforts to enhance the scientific rigor of clinical research in musculoskeletal trauma have highlighted several key outstanding needs that have not been met by most clinical studies to date. Large multicenter trials, international trials, large cohort outcome studies, and cost-benefit analyses are generally lacking in the orthopaedic trauma literature. There is an opportunity for clinical trials to produce broadly accepted treatment protocols.
Figures in this Article

    First Page Preview

    View Large
    />
    First page PDF preview
    Sign In to Your Personal ProfileSign In To Access Full Content
    Not a Subscriber?
    Get online access for 30 days for $35
    New to JBJS?
    Sign up for a full subscription to both the print and online editions
    Register for a FREE limited account to get full access to all CME activities, to comment on public articles, or to sign up for alerts.
    Register for a FREE limited account to get full access to all CME activities
    Have a subscription to the print edition?
    Current subscribers to The Journal of Bone & Joint Surgery in either the print or quarterly DVD formats receive free online access to JBJS.org.
    Forgot your password?
    Enter your username and email address. We'll send you a reminder to the email address on record.

     
    Forgot your username or need assistance? Please contact customer service at subs@jbjs.org. If your access is provided
    by your institution, please contact you librarian or administrator for username and password information. Institutional
    administrators, to reset your institution's master username or password, please contact subs@jbjs.org

    References

    Accreditation Statement
    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
    CME Activities Associated with This Article
    Submit a Comment
    Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
    Comments are moderated and will appear on the site at the discretion of JBJS editorial staff.

    * = Required Field
    (if multiple authors, separate names by comma)
    Example: John Doe





    Related Content
    The Journal of Bone & Joint Surgery
    JBJS Case Connector
    Topic Collections
    Related Audio and Videos
    PubMed Articles
    Guidelines
    Results provided by:
    PubMed
    Clinical Trials
    Readers of This Also Read...
    JBJS Jobs
    04/02/2014
    Illinois - Hinsdale Orthopaedics
    04/16/2014
    Connecticut - Yale University School of Medicine
    02/05/2014
    Oregon - The Center - Orthopedic and Neurosurgical Care and Research