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Langerhans Cell Histiocytosis of the AtlasA Report of Three Cases
Nobuhiro Tanaka, MD1; Yoshinori Fujimoto, MD2; Teruaki Okuda, MD1; Kazuyoshi Nakanishi, MD1; Tadayoshi Sumida, MD3; Hideki Manabe, MD3; Mitsuo Ochi, MD1
1 Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan. E-mail address for N. Tanaka: nobut@hiroshima-u.ac.jp
2 Department of Orthopaedic Surgery, Hiroshima General Hospital, Jigozen 1-3-3, Hatsukaichi, Hiroshima 738-8503, Japan
3 Department of Orthopaedic Surgery, Asa City Hospital, Kabeminami 2-1-1, Asakita-ku, Hiroshima 731-0293, Japan
View Disclosures and Other Information
The authors did not receive grants or outside funding in support of their research or preparation of this manuscript. They did not receive payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.
Investigation performed at the Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 2005 Oct 01;87(10):2313-2317. doi: 10.2106/JBJS.D.03008
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Langerhans cell histiocytosis sometimes involves the cervical spine and can be associated with collapse of the vertebral body1, but involvement of the atlas is rare. To the best of our knowledge, the cases of only eight patients with Langerhans cell histiocytosis of the atlas have been reported2-8.We report the cases of three patients with Langerhans cell histiocytosis of the atlas, two of whom appeared to have been successfully treated with low-dose chemotherapy. The patients and/or their parents were informed that information concerning the case would be submitted for publication.
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