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Histological Analysis of a Displaced Femoral Ring Allograft Spacer Filled with a Recombinant Human Bone Morphogenetic Protein-2-Soaked Collagen SpongeA Case Report
Joon Y. Lee, MD1; Steven Zeiller, MD2; Lysandra Voltaggio, MD2; Moe R. Lim, MD2; Alan S. Hilibrand, MD2; Alexander R. Vaccaro, MD2; D. Greg Anderson, MD2; Todd J. Albert, MD2
1 University of Pittsburgh Medical Center, Kaufmann Medical Building, 3471 5th Avenue, Suite 1010, Pittsburgh, PA 15213. E-mail address: joonyunglee@yahoo.com
2 Departments of Orthopaedic Surgery (S.Z., M.R.L., A.S.H., A.R.V., D.G.A., and T.J.A.) and Pathology (L.V.), Thomas Jefferson University Hospital, Rothman Institute, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107-4216
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The authors did not receive grants or outside funding in support of their research or preparation of this manuscript. They did not receive payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.
Investigation performed at Thomas Jefferson University Hospital and the Rothman Institute, Philadelphia, Pennsylvania

The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 2005 Oct 01;87(10):2318-2322. doi: 10.2106/JBJS.D.03034
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Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been tested as a bone-graft substitute in randomized, prospective clinical trials since 19971-4. In certain procedures, its efficacy with regard to both arthrodesis rates and clinical outcome has equaled that obtained with iliac crest bone graft. The United States Food and Drug Administration recently approved the use of rhBMP-2 as a bone-graft replacement during anterior lumbar interbody arthrodesis in conjunction with a tapered, threaded intervertebral cage (LT-CAGE; Medtronic Sofamor Danek, Minneapolis, Minnesota).
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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