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Severe Myelopathy Resulting from Melorheostosis of the Cervicothoracic SpineA Case Report
Steven C. Zeiller, MD1; Alexander R. Vaccaro, MD2; David W. Wimberley, MD1; Todd J. Albert, MD2; James S. Harrop, MD3; Alan S. Hilibrand, MD2
1 Department of Orthopaedic Surgery, Thomas Jefferson University, 1015 Chestnut Street, Philadelphia, PA 19107. E-mail address for S.C. Zeiller: zeiller@comcast.net
2 Thomas Jefferson University, Rothman Institute, 925 Chestnut Street, Philadelphia, PA 19107
3 Department of Neurosurgery, Jefferson Medical College, 909 Walnut Street, Second Floor, Philadelphia, PA 19107
View Disclosures and Other Information
The authors did not receive grants or outside funding in support of their research or preparation of this manuscript. They did not receive payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.
Investigation performed at the Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania

The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 2005 Dec 01;87(12):2759-2762. doi: 10.2106/JBJS.D.02653
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Melorheostosis is a rare, noninheritable, benign sclerosing bone dysplasia. The condition was originally described in 1922 by Leri and Joanny1. The disease process is of mesodermal origin, and the minimum prevalence is believed to be 0.9 cases per million2. Melorheostosis typically affects the long bones of the skeleton with the lower extremities being more commonly involved. In addition, the bones of the hand and foot may be involved with the disease process. Involvement of the axial skeleton, especially in Garver isolation, is very rare3. We describe a unique case of a patient who had severe spinal stenosis of the lower cervical and upper thoracic spine due to melorheostosis, resulting in progressive myelopathy. Our patient was notified that data concerning the case would be submitted for publication.
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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