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Osteosarcoma at the Site of a Previously Treated Aneurysmal Bone CystA Case Report
Chia-Chen Hsu, MD1; Jun-Wen Wang, MD1; Cheng-Hua Huang, MD1; Wei-Jen Chen, MD1
1 Departments of Orthopaedic Surgery (C.-C.H. and J.-W.W.), Hematology and Oncology (C.-H.H.), and Pathology (W.-J.C.), Chang Gung Memorial Hospital, 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung Hsien, 83305 Taiwan, Republic of China. E-mail address for J.-W. Wang: lee415@adm.cgmh.org.tw
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The authors did not receive grants or outside funding in support of their research or preparation of this manuscript. They did not receive payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.
Investigation performed at Chang Gung Memorial Hospital at Kaohsiung, Taiwan, Republic of China

The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 2005 Feb 01;87(2):395-398. doi: 10.2106/JBJS.C.01625
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Aneurysmal bone cyst is an expansile, destructive, hemorrhagic, non-neoplastic lesion that is thought to represent a benign reactive vascular process1-4. These lesions have been designated as either primary or secondary, with the latter term used when histological evaluation indicates a coexisting lesion, which can be either benign or malignant5,6.Occasionally, telangiectatic osteosarcomas have been misdiagnosed as aneurysmal bone cysts7-9, but the true nature of the malignant tumors usually became apparent after rapid progression or recurrence7. Like other benign tumors, aneurysmal bone cysts have been reported to have undergone malignant transformation, although most of the transformations were induced by irradiation7,10,11. In a review of the literature, only two well-documented reports of malignant transformation of an aneurysmal bone cyst without a history of irradiation were found. One transformation was to a malignant fibrous histiocytoma, and the other was to an osteosarcoma7,12.
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