0
Current Concepts Review   |    
Bone Morphogenetic ProteinsDevelopment and Clinical Efficacy in the Treatment of Fractures and Bone Defects
M.F. Termaat, MD1; F.C. Den Boer, MD, PhD2; F.C. Bakker, MD, PhD1; P. Patka, MD, PhD1; H.J.Th.M. Haarman, MD, PhD1
1 Department of Surgery and Traumatology, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. E-mail address for M.F. Termaat: mf.termaat@vumc.nl. E-mail address for F.C. Bakker: fc.bakker@vumc.nl. E-mail address for P. Patka: p.patka@vumc.nl. E-mail address for H.J.Th.M. Haarman: hjtm.haarman@vumc.nl
2 Department of Surgery, Sint Antonius Hospital, P.O. Box 2500, 3430 EM Nieuwegein, The Netherlands. E-mail address: frankdenboer@hotmail.com
View Disclosures and Other Information
Investigation performed at the Department of Surgery and Traumatology, VU University Medical Center, Amsterdam, The Netherlands

The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 2005 Jun 01;87(6):1367-1378. doi: 10.2106/JBJS.D.02585
5 Recommendations (Recommend) | 3 Comments | Saved by 3 Users Save Case

Abstract

The discovery of bone morphogenetic proteins marks a major step forward in the understanding of bone physiology and in the development of advanced methods in skeletal surgery.

The cornerstones for successful growth-factor therapy in skeletal surgery remain biomechanical stability and biological vitality of the bone providing an adequate environment for new bone formation.

Knowledge of the biological characteristics, mechanisms of action, and methods of delivery of growth factors will become essential for skeletal surgeons.

The current clinical application of bone morphogenetic proteins is safe and efficacious as a result of a well-regulated cascade of events leading to bone formation.

Clinical trials have not yet determined whether different clinical indications each require a specific bone-tissue-engineering format or if a single pathway for stimulating bone-healing with growth factors is sufficient.

Figures in this Article
    Sign In to Your Personal ProfileSign In To Access Full Content
    Not a Subscriber?
    Get online access for 30 days for $35
    New to JBJS?
    Sign up for a full subscription to both the print and online editions
    Register for a FREE limited account to get full access to all CME activities, to comment on public articles, or to sign up for alerts.
    Register for a FREE limited account to get full access to all CME activities
    Have a subscription to the print edition?
    Current subscribers to The Journal of Bone & Joint Surgery in either the print or quarterly DVD formats receive free online access to JBJS.org.
    Forgot your password?
    Enter your username and email address. We'll send you a reminder to the email address on record.

     
    Forgot your username or need assistance? Please contact customer service at subs@jbjs.org. If your access is provided
    by your institution, please contact you librarian or administrator for username and password information. Institutional
    administrators, to reset your institution's master username or password, please contact subs@jbjs.org

    References

    Accreditation Statement
    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
    CME Activities Associated with This Article
    Submit a Comment
    Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
    Comments are moderated and will appear on the site at the discretion of JBJS editorial staff.

    * = Required Field
    (if multiple authors, separate names by comma)
    Example: John Doe





    Related Content
    The Journal of Bone & Joint Surgery
    JBJS Case Connector
    Topic Collections
    Related Audio and Videos
    PubMed Articles
    Clinical Trials
    Readers of This Also Read...
    JBJS Jobs
    12/31/2013
    SC - Department of Orthopaedic Surgery Medical Univerity of South Carlonina
    03/19/2014
    VA - OrthoVirginia
    10/04/2013
    CA - Mercy Medical Group