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Letters to the Editor   |    
Craig T. Hartrick, MD; Gavin Martin, MD
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These letters originally appeared, in slightly different form, on jbjs.org. They are still available on the web site in conjunction with the article to which they refer.

The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 2006 Nov 01;88(11):2536-2536
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Extract

C.T. Hartrick and G. Martin reply:We appreciate both Dr. Boezaart's interest and his concern. The facts do indeed speak for themselves. The adverse event figures as quoted above pertained to all groups, which included the intravenous patient-controlled analgesia with morphine arm. This highlights an important point that we hope that we made clear in our discussion but welcome the opportunity to emphasize. Morphine produces similar adverse effects regardless of the route of administration. The prevalence of side effects in all groups should be taken in the context of the study protocol, in which no prophylaxis with drugs such as ondansetron was allowed. Furthermore, DepoDur was not dosed according to age but rather by random assignment.
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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