J.O. Anglen replies:I thank Mr. Todkar for his interest in my paper and this topic. I agree
entirely with his opinion that some antiseptics, such as hydrogen peroxide,
may be detrimental to open fracture wound-healing. I would caution against the
use of any antiseptic solution in open fracture wounds because of the damage
that is done to host tissues and immune cells. I also agree that irrigation of
open fracture wounds is a poor method of antibiotic delivery, and, for that
reason, the practice does not make much sense.