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The Influence of Antibiotics on the Fatigue Life of Acrylic Bone Cement
Paul D. Postak, BSc; A. Seth Greenwald, DPhil(Oxon)
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Orthopaedic Research Laboratories (the corporation by which the authors are employed) received equal amounts from DePuy, Smith and Nephew, and Stryker to participate in this comparative analysis. No author was directly paid by the companies nor were contributions made to any foundations or charities in the name of Orthopaedic Research Laboratories or in the names of the authors.

The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 2006 Dec 01;88(suppl 4):148-155. doi: 10.2106/JBJS.F.00586
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Aseptic loosening attributed to cement fracture and subsequent disruption of fixation interfaces remains a major long-term mode of failure of arthroplasties performed with cement1 (Fig. 1). The fracture strength of bone cement, especially in fatigue, is an important indicator of cement integrity and the potential for fixation failure.In current practice, orthopaedic surgeons may choose to utilize antibiotics in bone cement for prophylaxis or treatment of a known infection. However, the antibiotics, bone cement, and mixing method employed lead to variability in the quality of the end product2-5.
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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