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Donor Cell Survival in a Fresh Osteochondral Allograft at Twenty-nine YearsA Case Report
Amir A. Jamali, MD1; Sandra L. Hatcher, MSc, CLSp (MB)2; Zongbing You, PhD1
1 Department of Orthopaedic Surgery, University of California Davis Medical Center, 4860 Y Street, #3800, Sacramento, CA 95817. E-mail address for A.A. Jamali: ajamali@ucdavis.edu. E-mail address for Z. You: zyou@ucdavis.edu
2 Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, 3740 Business Drive, Sacramento, CA 95820. E-mail address: sandra.hatcher@ucdmc.ucdavis.edu
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Disclosure: The authors did not receive grants or outside funding in support of their research for or preparation of this manuscript. They did not receive payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.
Investigation performed at the University of California Davis Medical Center, Sacramento, California

The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 2007 Jan 01;89(1):166-169. doi: 10.2106/JBJS.F.00618
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Fresh osteochondral allografting is a nonvascularized organ transplantation with a clinical use dating back to the early twentieth century. The procedure, in its current form, involves transplantation of a small segment of bone as a carrier with its overlying cartilage. As the bone is remodeled and revascularized by the recipient, the donor cartilage continues to function mechanically, produces matrix, and receives nutrition from the synovial fluid. The cartilage has traditionally been considered a so-called immunoprivileged tissue, avoiding the immune surveillance of the host presumably because of its paucity of vascular channels and its hypo-cellular matrix1. These qualities make fresh osteochondral allografting unique in the field of transplantation and preclude the need for systemic immunosuppression after this procedure. Although histologically normal articular cartilage has been reported in retrieved fresh osteochondral allografts, we know of no report that has definitively confirmed the specific survival of the donor cells for any length of time. Furthermore, the source of cells in retrieved transplants has not been confirmed as being from the donor or the recipient. The patient was informed that data concerning his case would be submitted for publication.
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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