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Malignant Transformation of Synovial Chondromatosis of the Shoulder to ChondrosarcomaA Case Report
Alexander P. Sah, MD1; David S. Geller, MD1; Henry J. Mankin, MD1; Andrew E. Rosenberg, MD1; Thomas F. DeLaney, MD1; Cameron D. Wright, MD1; Francis J. Hornicek, MD, PhD1
1 Department of Orthopaedic Surgery (A.P.S., and D.S.G.), Cartilage Biology and Orthopaedic Oncology Laboratories (H.J.M.), Department of Pathology (A.E.R.), Department of Radiation Oncology (T.F.DeL.), Surgery Service (C.D.W.), and the Center for Sarcoma and Connective Tissue Oncology (F.J.H.), Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114. E-mail address for A.P. Sah: asah@partners.org
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Disclosure: The authors did not receive any outside funding or grants in support of their research for or preparation of this work. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, division, center, clinical practice, or other charitable or nonprofit organization with which the authors, or a member of their immediate families, are affiliated or associated.
Investigation performed at the Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts

The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 2007 Jun 01;89(6):1321-1328. doi: 10.2106/JBJS.F.00511
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Primary synovial chondromatosis is a proliferation of cartilaginous bodies within the synovial membrane, bursa, or tendon sheath. Historically, it has been characterized as a rare, monoarticular, benign arthropathy of uncertain etiology, typically involving a single large joint in a young adult. Males are affected more commonly than females1. The knee is involved most frequently, followed by the hip, elbow, shoulder, ankle, and wrist2-4; however, smaller joint involvement, including that of the spine, foot, and hand, has been reported5-8, as has involvement of the acromioclavicular, temporomandibular, and sternoclavicular joints9-12. The Massachusetts General Hospital tumor database contains eighty-six recorded cases of synovial chondromatosis; these cases include involvement of the knee (thirty-three cases), the hip (sixteen cases), the shoulder (eight cases), the ankle (seven cases), the foot (seven cases), the elbow (five cases), and miscellaneous locations (ten cases).
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