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Invasive Group-A Streptococcal Infection in an Allograft RecipientA Case Report
Ellen H. Lee, MD1; Dayna Ferguson, MD1; Daniel Jernigan, MD, MPH2; Melissa Greenwald, MD3; Timothy Coté, MD3; Jon E. Bos, MPH4; Jeannette Guarner, MD5; Sherif Zaki, MD, PhD5; Anne Schuchat, MD1; Bernard Beall, PhD1; Arjun Srinivasan, MD2
1 Epidemic Intelligence Service, Career Development Division, Office of Workforce and Career Development (E.H.L. and D.F.) and Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases (E.H.L., A.S., B.B.), Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop C-23, Atlanta, GA 30333
2 Epidemiology Section, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop A-35, Atlanta, GA 30333. E-mail address for A. Srinivasan: beu8@cdc.gov
3 Center for Biologics Evaluation and Research, United States Food and Drug Administration, 1401 Rockville Pike, Suite 200N, Rockville, MD 20852-1448
4 Oklahoma State Department of Health, 1000 N.E. 10th Street, Oklahoma City, OK 73117-1299
5 Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop G-32, Atlanta, GA 30333
View Disclosures and Other Information
Disclosure: The authors did not receive any outside funding or grants in support of their research for or preparation of this work. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, division, center, clinical practice, or other charitable or nonprofit organization with which the authors, or a member of their immediate families, are affiliated or associated.
The views presented here are those of the authors and should not be construed as reflecting the views of the Centers for Disease Control and Prevention or Food and Drug Administration.
Investigation performed at the Centers for Disease Control and Prevention, Atlanta, Georgia

The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 2007 Sep 01;89(9):2044-2047. doi: 10.2106/JBJS.F.01594
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Each year, approximately 1.5 million musculoskeletal allografts are distributed for transplantation1. Allograft tissues offer advantages over autografts, such as smaller surgical incisions, reduced operative times, and lack of donor-site morbidity2. A disadvantage of allografts is the potential, albeit low, for disease transmission. Recent investigations have implicated a variety of allografts in the transmission of several microorganisms3-7. We investigated the occurrence of invasive group-A streptococcal disease in a musculoskeletal allograft recipient.
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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