Case Reports   |    
Nonresectable Multiple Lung Metastases of High-Grade Osteosarcoma of the Humerus: Stable After Twelve YearsA Case Report
Emanuela Palmerini, MD1; Eric L. Staals, MD1; Stefano Ferrari, MD1; Raffaella Rinaldi, MD1; Marco Alberghini, MD1; Mario Mercuri, MD1; Gaetano Bacci, MD1
1 Chemotherapy Unit (E.P., S.F., and G.B.), Orthopaedic Surgery (E.L.S. and M.M.), Radiology (R.R.), and Pathology (M.A.), Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, via Pupilli 1, 40136 Bologna, Italy. E-mail address for E. Palmerini: emanuela.palmerini@ior.it
View Disclosures and Other Information
Disclosure: The authors did not receive any outside funding or grants in support of their research for or preparation of this work. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, division, center, clinical practice, or other charitable or nonprofit organization with which the authors, or a member of their immediate families, are affiliated or associated.
Investigation performed at the Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy

The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2008 Oct 01;90(10):2240-2244. doi: 10.2106/JBJS.G.01619
5 Recommendations (Recommend) | 3 Comments | Saved by 3 Users Save Case


Thanks to the combination of surgery and adjuvant or neoadjuvant chemotherapy, the outcome for patients with nonmetastatic osteosarcoma of an extremity has improved dramatically over the last twenty years. For this group of patients, the five-year overall rate of survival increased from less than 15% in the 1970s1,2 to more than 65% as of the time of writing3,4. Patients with osteosarcoma of the extremity who present with lung metastasis (about 20% of all cases) have a poorer prognosis than those without metastases. Nonetheless, with the combination of chemotherapy and complete surgical removal of primary and secondary lesions, the survival of patients with metastases has improved from less than 5% to more than 20%5,6. However, when complete excision of all of the secondary lesions is impossible, the five-year survival rate becomes extremely low and almost all of these patients die within three years from the time of diagnosis5.
Figures in this Article

    First Page Preview

    View Large
    First page PDF preview
    Sign In to Your Personal ProfileSign In To Access Full Content
    Not a Subscriber?
    Get online access for 30 days for $35
    New to JBJS?
    Sign up for a full subscription to both the print and online editions
    Register for a FREE limited account to get full access to all CME activities, to comment on public articles, or to sign up for alerts.
    Register for a FREE limited account to get full access to all CME activities
    Have a subscription to the print edition?
    Current subscribers to The Journal of Bone & Joint Surgery in either the print or quarterly DVD formats receive free online access to JBJS.org.
    Forgot your password?
    Enter your username and email address. We'll send you a reminder to the email address on record.

    Forgot your username or need assistance? Please contact customer service at subs@jbjs.org. If your access is provided
    by your institution, please contact you librarian or administrator for username and password information. Institutional
    administrators, to reset your institution's master username or password, please contact subs@jbjs.org


    Accreditation Statement
    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
    CME Activities Associated with This Article
    Submit a Comment
    Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
    Comments are moderated and will appear on the site at the discretion of JBJS editorial staff.

    * = Required Field
    (if multiple authors, separate names by comma)
    Example: John Doe

    Related Content
    The Journal of Bone & Joint Surgery
    JBJS Case Connector
    Topic Collections
    Related Audio and Videos
    PubMed Articles
    Clinical Trials
    Readers of This Also Read...
    JBJS Jobs
    IL - Hinsdale Orthopaedics
    NY - Modern Chiropractic Care, P.C.
    OK - The University of Oklahoma