The Orthopaedic Forum   |    
An AAOS-NIH SymposiumFracture Repair: Challenges, Opportunities, and Directions for Future Research*
Thomas A. Einhorn, MD1; Cato T. Laurencin, MD, PhD2; Karen Lyons, PhD3
1 Department of Orthopaedic Surgery, Boston University Medical Center, 720 Harrison Avenue, Suite 808, Boston, MA 02118. E-mail address: thomas.einhorn@bmc.org
2 Department of Orthopaedic Surgery, University of Virginia, 400 Ray C. Hunt Drive, Suite 300, Charlottesville, VA 22936. E-mail address: laurencin@virgnia.edu
3 Department of Orthopaedic Surgery, University of California, Los Angeles, 615 Charles E. Young Drive South, 410C OHRC, Los Angeles, CA 90095. E-mail address: klyons@mednet.ucla.edu
View Disclosures and Other Information
This article is a summary of the American Academy of Orthopaedic Surgeons-National Institutes of Health Symposium, Miami Beach, Florida, April 25 through 28, 2007.
Disclosure: In support of their research for or preparation of this work, one or more of the authors received, in any one year, outside funding or grants in excess of $10,000 from the National Institutes of Health (AR44528, AR049920, and AR52686). Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, division, center, clinical practice, or other charitable or nonprofit organization with which the authors, or a member of their immediate families, are affiliated or associated.

The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2008 Feb 01;90(2):438-442. doi: 10.2106/JBJS.G.01092
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Fracture-healing is a complex, highly organized biological process that leads to the restoration of skeletal integrity by the regeneration of bone. This unique property differentiates bone from other tissues and is essential for skeletal health, homeostasis, and survival. Although fracture-healing is one of the most consistent and reliable reparative responses of human tissue, its impairment or failure can lead to devastating clinical consequences. Conversely, a comprehensive understanding of the basic science of fracture-healing may reveal some of the most well-kept secrets of nature, providing clinicians and scientists with new paths for investigation and leading to advanced therapies for the treatment of skeletal injuries and diseases. This article summarizes the key discussion points of the 2007 American Academy of Orthopaedic Surgeons (AAOS) Research Symposium entitled "Fracture Repair: Challenges and Opportunities." The major goals of this meeting were (1) to identify the unmet needs and research directions for basic, translational, and clinical research in fracture-healing so as to guide the scientific community, and (2) to provide critical feedback to the National Institutes of Health (NIH) to impact their long-range planning and priority-setting processes.
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