Cast treatment has been a mainstay of fracture management for decades. In an age when surgical treatment is thought to be first-line therapy for many fractures, cast treatment is often considered to be the conservative mode of care. Cast treatment is not, however, without its own risks of complication. One of the recognized complications from cast application is thermal injury. In order to minimize this risk, isopropyl alcohol is often applied to fiberglass casts during the curing stage. We present a rare case of transcutaneous isopropyl alcohol poisoning in a child undergoing cast management of a femoral fracture. The parents of the child were informed that data concerning the case would be submitted for publication, and they consented. Our institutional review board exempts case reports from the approval process.